Publications by authors named "Elizabeth S Gaytan"
Article Synopsis
- RNA-binding proteins (RBPs) are crucial for memory and cognitive function, with dysfunction linked to neurological disorders, but many of the 2,000 RBPs in humans are uncharacterized.
- Researchers used the model organism C. elegans to discover eight new memory regulators among 20 conserved RBPs, focusing on CEY-1, which resembles the mammalian Y-Box RBPs.
- They found that CEY-1 is necessary and sufficient for memory, and identified a potentially harmful variant (p.Asn127Tyr) in human YBX3 that leads to memory deficits in worms, suggesting YBX dysfunction could contribute to neurological diseases.
RNA-binding proteins (RBPs) regulate translation and plasticity which are required for memory. RBP dysfunction has been linked to a range of neurological disorders where cognitive impairments are a key symptom. However, of the 2,000 RBPs in the human genome, many are uncharacterized with regards to neurological phenotypes.
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