Marine aquaculture (mariculture), the farming of marine species, is currently a relatively small contributor to the United States' seafood industry. There is tremendous potential for growth in this sector and increasing interest in advancing the industry through supportive federal and state policies as well as concerns about how to best manage potential negative impacts or unsustainable development. While some mariculture is conducted in land-based tanks as well as saltwater ponds, and there are pilot projects and ongoing applications to commence mariculture operations in federal waters, the majority of mariculture activities occur within state waters (typically, 3 nautical miles, or 5.
View Article and Find Full Text PDFCurr Drug Metab
August 2023
Background And Objective: Protein kinases known as mitogen-activated protein kinases (MAPKs) are responsible for regulating a wide variety of physiological cell responses by generating and release of inflammatory mediators. Suppressing these inflammatory mediators can be utilized to control the propagation of inflammation. During the course of this research, we created folate-targeted MK2 inhibitor conjugates and analyzed the antiinflammatory effects of these compounds.
View Article and Find Full Text PDFSynthetic textiles can shed numerous microfibers during conventional washing, but evaluating environmental consequences as well as source-control strategies requires understanding mass releases. Polyester apparel accounts for a large proportion of the polyester market, and synthetic jackets represent the broadest range in apparel construction, allowing for potential changes in manufacturing as a mitigation measure to reduce microfiber release during laundering. Here, detergent-free washing experiments were conducted and replicated in both front- and top-load conventional home machines for five new and mechanically aged jackets or sweaters: four from one name-brand clothing manufacturer (three majority polyester fleece, and one nylon shell with nonwoven polyester insulation) and one off-brand (100% polyester fleece).
View Article and Find Full Text PDFObjective: To determine the feasibility of using volunteers to assist in school-located mass vaccination clinics for influenza.
Methods: A set of elementary school-based mass vaccination clinics was implemented in Carroll County, Maryland by the local health department in the 2005-2006 school year. In addition to using health department personnel, fiscal restraints necessitated using medical volunteers and lay volunteers to assist health professionals.
Objective: The objective of this study was to evaluate the feasibility of a school-based influenza immunization program.
Methods: Pupils and their families from 3 demographically similar elementary schools participated in this pilot, unblinded, controlled intervention study. Live attenuated influenza vaccine (FluMist) was made available to all eligible pupils in 1 target school during regular school hours.
Arch Gen Psychiatry
August 2005
Context: Adaptations in gamma-aminobutyric acid type A (GABA(A))-benzodiazepine receptors contribute to the neurobiology of human alcohol dependence and withdrawal.
Objective: To study GABA(A)-benzodiazepine receptor adaptations in subjects with alcohol dependence over the first month of sobriety.
Design: Inpatients who were not receiving medication, were either smokers or nonsmokers, and had alcohol dependence completed 2 iodine I 123-labeled iomazenil single-photon emission computed tomographic scans: 1 scan at a mean +/- SD of 4.