Food dependence in rats selectively bred for low versus high saccharin intake. Implications for "food addiction".

The "food addiction" concept implies that proneness to drug dependence and to food dependence should covary. The latter was studied in low- (LoS) and high- (HiS) saccharin-consuming rats, who differ in drug self-administration (HiS>LoS) and withdrawal (LoS>HiS). Sugary food intake in the first 1-2 h was higher in HiS than LoS rats.

Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder.

Background: Consistent with the clinical picture of milder symptomatology in schizotypal personality disorder (SPD) than schizophrenia, morphological studies indicate SPD abnormalities in temporal lobe regions but to a much lesser extent in prefrontal regions implicated in schizophrenia. Lower fractional anisotropy (FA), a measure of white-matter integrity within prefrontal, temporal, and cingulate regions has been reported in schizophrenia but has been little studied in SPD.

Aims: The study aim was to examine temporal and prefrontal white matter FA in 30 neuroleptic-naïve SPD patients and 35 matched healthy controls (HCs).