Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis.

Introduction: Focal segmental glomerulosclerosis (FSGS), the most common primary glomerular disease leading to end-stage kidney disease (ESKD), is characterized by podocyte injury and depletion, whereas minimal change disease (MCD) has better outcomes despite podocyte injury. Identifying mechanisms capable of preventing podocytopenia during injury could transform FSGS to an "MCD-like" state. Preclinical data have reported conversion of an MCD-like injury to one with podocytopenia and FSGS by inhibition of AMP-kinase (AMPK) in podocytes.

A Qualitative Examination of Work, Families, and Schools in Low-Income Latinx Communities During Strict Immigration Enforcement.

Education policy and the role of schools are a neglected part of the welfare state. Yet schools may be important sites for understanding how policy, work, and families intersect in immigrant households. Drawing on thirty interviews from seventeen households, this article highlights the experiences of families with young children during a time of increased national hostility toward immigrants.

Feline ophthalmomyiasis externa caused by larvae: four cases (2005-2020).

Case Series Summary: Described are four cats diagnosed with ophthalmomyiasis externa caused by larvae. Medical records were retrospectively reviewed to identify cats with ophthalmomyiasis externa between 2005 and 2020 at Cornell University Hospital for Animals. Signalment, history, clinical and diagnostic findings, treatment and outcome were recorded.

A Masquerader of Disease: An Incomplete Presentation of Kawasaki Disease.

Kawasaki disease (KD) is a systemic pediatric vasculitis that most commonly affects children between the ages of 6 months and 4 years. The diagnosis of KD requires a high degree of clinical suspicion. In younger patients (less than 6 months) the diagnosis is exceedingly difficult as these patients typically do not meet the criteria to diagnosis KD clinically.

What the Joint Admission Medical Program (JAMP) can do for Texas physicians; what Texas physicians can do for JAMP.

Texas faces health challenges requiring a physician workforce with understanding of a broad range of issues -- including the role of culture, income level, and health beliefs -- that affect the health of individuals and communities. Building on previous successful physician workforce "pipeline" efforts, Texas established the Joint Admission Medical Program (JAMP), a first-of-its-kind program to encourage access to medical education by Texans who are economically disadvantaged. The program benefits those from racial and ethnic minority groups and involves all 31 public and 34 private Texas undergraduate colleges and universities offering life science degrees, as well as all 9 medical schools.

Cardiovascular reactivity in fibromyalgia: evidence for pathogenic heterogeneity.

Objective: To evaluate disease-specific cardiovascular reactivity patterns in patients with fibromyalgia (FM) using a recently described method called fractal and recurrence analysis score (FRAS).

Methods: The study group included 30 women with FM, average age 46.7 years (SD 7.