Publications by authors named "Elizabeth P Levy"
The respiratory epithelium consists of lung sentinel cells, which are the first to contact inhaled inflammatory insults, including air pollutants, smoke, and microorganisms. To avoid damaging exuberant or chronic inflammation, the inflammatory process must be tightly controlled and terminated once the insult is mitigated. Inflammation resolution is now known to be an active process involving a new genus of lipid mediators, called "specialized proresolving lipid mediators," that includes resolvin D1 (RvD1).
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- Cigarette smoke triggers strong inflammation leading to lung diseases like COPD, and resolution of this inflammation is an active process, involving specialized lipid mediators derived from omega-3 and omega-6 fatty acids.
- RvD1, a specific lipid mediator, shows potential in reducing inflammation in lung models by suppressing harmful pro-inflammatory substances and enhancing protective factors, both during and after exposure to cigarette smoke.
- The study's findings suggest that RvD1 could be a valuable therapeutic agent for managing lung inflammation linked to smoking, promoting quicker recovery by fostering anti-inflammatory responses and beneficial macrophage activities.