Retinopathy of prematurity in infants with birth weights greater than 1250 grams.

Purpose: To determine whether severe retinopathy of prematurity (ROP) occurs in infants whose birth weights exceed 1250 g.

Methods: We retrospectively reviewed the medical records of 1118 premature infants with birth weights > 1250 g, who were referred for screening examinations for ROP, to determine the severity of ROP observed. We then cross-tabulated these data with each infant's estimated gestational age and birth weight.

Nuclear factor kappaB mediates a procoagulant response in monocytes during extracorporeal circulation.

Objective: The objective of this study was to examine the mechanism of procoagulant activity and inhibition in whole blood during extracorporeal circulation.

Methods: In this study we examine the development of procoagulant activity and monocyte activation in heparinized whole blood passing through a closed circuit consisting of a pump and silicone envelope membrane oxygenator for 6 hours.

Results: Anaphylatoxins, C3a and C5a, determined by means of enzyme-linked immunosorbant assay, appeared in the blood within 30 minutes of circulation.