Publications by authors named "Elizabeth M Randall"
PLoS Pathog
February 2019
Article Synopsis
- Paramyxoviruses can cause long-lasting infections that may lead to chronic diseases, but the specific molecular processes behind this are not well understood.
- Using parainfluenza virus type 5 (PIV5) as a study model, researchers discovered that the phosphorylation of a protein called P is crucial for determining whether the virus will either become repressed or continue to replicate late in the infection.
- Variants of the P protein can shift the infection from a lytic (cell-killing) outcome to a persistent one, with lytic variants initially replicating more efficiently but being cleared from the body faster as the immune system responds.
