Development of a Robust and Quantitative High-Throughput Screening Method for Antibiotic Production in Bacterial Libraries.

Over the past 30 years, there has been a dramatic rise in the number of infections caused by multidrug-resistant bacteria, which have proliferated due to the misuse and overuse of antibiotics. Over this same time period, however, there has also been a decline in the number of antibiotics with novel mechanisms of action coming to market. Therefore, there is a growing need for an increase in the speed at which new antibiotics are discovered and developed.

Neutron versus photon radiotherapy for local control in inoperable breast cancer.

Background And Purpose: By virtue of their high linear energy transfer (LET) characteristics the biologic effectiveness of neutrons is less dependent on tissue oxygenation tension and cell cycle phase as compared to that with photons. Hence, an improved clinical benefit is to be expected predominantly in large, hypoxic and slowly growing tumors. Since a short course of radiotherapy is required for clinical reasons, it prompted the authors to initiate a randomly controlled trial on locally advanced breast cancer.

Medical and radiation oncology for breast cancer in developing countries with particular reference to locally advanced breast cancer.

The first part of this review outlines the extent of the problem of breast cancer in developing countries, with particular reference to the difficulties surrounding breast cancer treatment in these countries. The second part is devoted to discussion of chemotherapy, hormonal therapy, and radiotherapy treatments suitable for developing countries. The goals of the review are to show how treatment strategies can be adapted in poorer countries and how oncologists from the developed world can play a role in developing countries.