Operative management and outcomes of gallbladder cancer in Australia: a multi-institutional, retrospective, observational cohort analysis.

Background: Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease-free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for gallbladder cancer in the Australian context, and assesses factors associated with post-operative morbidity.

Methods: Multi-centre, retrospective cohort analysis including all gallbladder cancer patients who underwent resection across six Australian institutions between January 2010 and January 2020.

Evaluation of a chat GPT generated patient information leaflet about laparoscopic cholecystectomy.

Background: Artificial intelligence is increasingly being used in all aspects of life in information compilation and writing, and this includes healthcare. This study aimed to evaluate a Chat GPT generated patient information leaflet (PIL) against a surgeon generated version, in order to explore a potential application of this artificial intelligence language processing model.

Methods: Cross-sectional study, undertaken May to June 2023, asking two cohorts (patients and doctors) to complete a questionnaire evaluating a Chat GPT generated PIL and a surgeon generated PIL about laparoscopic cholecystectomy.

Comparison of risk adjusted excess post-operative pancreatic fistula rates after pancreaticoduodenectomy using cumulative sum analysis.

Background: Post-operative pancreatic fistula (POPF) is a key outcome post pancreaticoduodenectomy. There are numerous POPF risk calculators but no agreed benchmark, a key component of meaningful audit. We compared observed versus predicted POPF for six risk adjusted POPF calculators, to ascertain how they differ and thus contribute to discussion around benchmarking.

Identification of the optimal growth charts for use in a preterm population: An Australian state-wide retrospective cohort study.

Background: Preterm infants are a group at high risk of having experienced placental insufficiency. It is unclear which growth charts perform best in identifying infants at increased risk of stillbirth and other adverse perinatal outcomes. We compared 2 birthweight charts (population centiles and INTERGROWTH-21st birthweight centiles) and 3 fetal growth charts (INTERGROWTH-21st fetal growth charts, World Health Organization fetal growth charts, and Gestation Related Optimal Weight [GROW] customised growth charts) to identify which chart performed best in identifying infants at increased risk of adverse perinatal outcome in a preterm population.

Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs.

Background: It is not known whether fasting affects levels of circulating placenta-specific transcripts.

Objective: To assess whether a glucose load affects circulating placenta-specific transcripts.

Method: RNA was extracted from paired blood samples (fasting and 1-h post 75 g oral glucose) from 22 women.