Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders.

Objective: To systematically evaluate the efficacy of treatments for tics and the risks associated with their use.

Methods: This project followed the methodologies outlined in the 2011 edition of the American Academy of Neurology's guideline development process manual. We included systematic reviews and randomized controlled trials on the treatment of tics that included at least 20 participants (10 participants if a crossover trial), except for neurostimulation trials, for which no minimum sample size was required.

Practice guideline recommendations summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders.

Objective: To make recommendations on the assessment and management of tics in people with Tourette syndrome and chronic tic disorders.

Methods: A multidisciplinary panel consisting of 9 physicians, 2 psychologists, and 2 patient representatives developed practice recommendations, integrating findings from a systematic review and following an Institute of Medicine-compliant process to ensure transparency and patient engagement. Recommendations were supported by structured rationales, integrating evidence from the systematic review, related evidence, principles of care, and inferences from evidence.