Food allergy in adults and children.

Food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food and is distinct from food intolerance. Clinical manifestations of food allergy are varied and involve many systems including respiratory, cutaneous, and gastrointestinal. The double-blinded placebo-controlled oral food challenge remains the gold standard for the diagnosis of IgE-mediated food allergy.

Palliative care for the patient with refractory chronic rhinosinusitis.

Most otolaryngologists encounter patients with chronic rhinosinusitis who, despite conventional medical and surgical therapy, fail to show significant symptomatic improvement. Many paradigms have been proposed to explain the mechanisms responsible for refractory disease in these patients, including superantigen activation, biofilm formation, and eosinophil activation triggered by fungal elements. Although the precise underlying etiology of this clinical scenario remains unclear, the resultant pathophysiologic events share a final common pathway marked by inflammatory changes of the sinonasal mucosa.

Analysis of recurrent angiotensin converting enzyme inhibitor-induced angioedema.

Objective/hypothesis: A known risk for patients taking angiotensin converting enzyme-inhibitors (ACE-Is) is angioedema that can involve the face, lips, oral cavity, and larynx. Such upper airway obstruction may be severe enough to require an emergency department visit or even necessitate prompt airway intervention. Once a patient has had an episode of ACE-inhibitor induced angioedema (AIIA), certainly a thrust of continuing case management would be to avoid the occurrence of subsequent episodes of AIIA that potentially can be life-threatening.

Angioedema and angiotensin-converting enzyme inhibitors: are demographics a risk?

Objectives: The use of angiotensin-converting enzyme inhibitors (ACEI) has become the leading cause of acquired angioedema. Previous studies have suggested that certain patient populations may be at a higher risk for ACEI-induced angioedema. The objective of this study was to evaluate any demographic associations.

New classification of nasal vasculature patterns in hereditary hemorrhagic telangiectasia.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a disorder characterized by the triad of recurrent epistaxis, telangiectasia, and a family history of the disease. Management of recalcitrant epistaxis in HHT remains a challenging problem for otolaryngologists. The precise coagulation of telangiectasias with the Nd-YAG laser has shown efficacy in the treatment:of HHT-associated epistaxis, but results can be variable and patient selection is critical in ensuring a successful outcome.

Surgical reconstruction of lentigo maligna defects.

Objective: To review our experience with lentigo maligna, a melanoma in situ that occurs primarily on the head and neck in older adults, and reconstructive efforts applied in managing the large defects following lentigo maligna excision that are not amenable to primary closure.

Methods: We reviewed the records of 23 patients who underwent serial excision of lentigo maligna using a modified Mohs technique. We compared the sizes of the initial lesion and postexcision defect, examined photographs taken before and after surgery, and studied techniques used in reconstruction.

Evaluation and management of malignant cervical lymphadenopathy with an unknown primary tumor.

Patients with malignant cervical lymphadenopathy without an evident primary site are considered to have an unknown primary tumor.Several management concerns arise in this situation including how best to seek a primary site and, if none is identified, how to treat these patients. This article discusses theories as to the etiology of the unknown primary tumor, diagnostic modalities highlighting the role of emerging technologies, and treatment strategies.

Sjögren's disease.

In summary, Sjögren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, particularly the salivary and lacrimal glands. The sicca complex of xerophthalmia and xerostomia are the hallmark features of Sjögren's symptomatology. In addition to these hallmark symptoms of oral and ocular dryness, one third of patients with Sjögren's syndrome present with extraglandular manifestations.