Publications by authors named "Elizabeth Herrity"

Article Synopsis
  • Primary Central Nervous System Lymphoma (PCNSL) is a highly aggressive lymphoma affecting the brain and central nervous system, with poor survival rates (30-40% over five years), particularly for patients with relapsed or refractory cases.
  • *Recent research has identified key oncogenic drivers of PCNSL, including NFkB pathway activation and immune evasion, prompting the development of targeted therapies and immunotherapies.
  • *Emerging treatments, such as BTK inhibitors, immune checkpoint inhibitors, and CAR T-cell therapies, indicate a shift towards a multi-modality approach combining intensive chemotherapy and innovative therapies to improve patient outcomes.*
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Emerging biological and clinical data, along with advances in new technologies, have exposed the mechanistic diversity in post-haematopoietic stem cell transplant (HCT) relapse. Post-HCT relapse mechanisms are relevant for guiding sophisticated selection of therapeutic interventions and identification of areas for further research. Clonal evolution and emergence of resistant leukemic strains is a common mechanism shared by relapse post-chemotherapy and post-HCT, other mechanisms such as leukemic immune escape and donor T cell exhaustion are unique entities to post-HCT relapse.

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Improved understanding of TP53 biology and the clinicopathological features of TP53-mutated myeloid neoplasms has led to the recognition of TP53-mutated acute myeloid leukemia/myelodysplastic syndrome (TP53m AML/MDS) as a unique entity, characterized by dismal outcomes following conventional therapies. Several clinical trials have investigated combinations of emerging therapies for these patients with the poorest molecular prognosis among myeloid neoplasms. Although some emerging therapies have shown improvement in overall response rates, this has not translated into better overall survival, hence the notion that p53 remains an elusive target.

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