Publications by authors named "Elizabeth Hailu"
Primary ciliary dyskinesia (PCD) is a rare, motile ciliopathy inherited through mostly autosomal recessive variants that results in chronic ear, sinus, and respiratory disease. Despite neonatal respiratory distress being a common presenting symptom in term infants with PCD, the diagnosis is often delayed due to non-familiarity of neonatal caregivers with phenotypic and diagnostic features of this disease. Organ laterality defects, prenatal cerebral ventriculomegaly, and a family history of suppurative respiratory disease may occur in PCD and should prompt neonatal testing for this condition.
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- - The study evaluated the impact of a new bCPAP protocol on respiratory outcomes for infants born before 32 weeks of gestation and weighing under 1250 g, spanning four time periods from 2012 to 2020.
- - Results indicated that the implementation of the bCPAP protocol significantly reduced the rates of death and severe bronchopulmonary dysplasia (BPD), with intubation rates also decreasing over time—especially in the delivery room.
- - The findings suggest that using bCPAP as primary respiratory support improves outcomes for very preterm infants, demonstrating the effectiveness of this comprehensive protocol in clinical practice.
Article Synopsis
- The study aimed to test the safety and feasibility of sildenafil in neonates with neonatal encephalopathy (NE) who were not responding well to therapeutic hypothermia (TH).
- Conducted as a randomized, double-blind clinical trial, the research included 24 neonates, with 8 receiving sildenafil and 3 a placebo, examining outcomes like safety and brain recovery over 30 days and 18 months.
- Results showed that sildenafil was generally safe, with some signs of brain recovery in treated neonates, but further research is needed to determine effective dosing and confirm these findings in larger trials.