Publications by authors named "Elizabeth Dorans"
Article Synopsis
- - Methods for linking regulatory elements to genes using single-cell RNA-seq and ATAC-seq multiome data have varied success due to differences in handling noise and genomic distance, leading to inconsistent results.
- - The new framework, pgBoost, combines multiple linking strategies and incorporates genomic distance, resulting in significantly better identification of SNP-gene relationships, especially over larger distances compared to existing methods.
- - pgBoost demonstrates superior performance in connecting SNPs to genes validated by CRISPR and GWAS data, revealing important links that other methods failed to identify, especially when focused on specific cell types.
