Impact of a Devastating Brain Injury Pathway on Outcomes, Resources, and Organ Donation: 3 Years' Experience in a Regional Neurosciences ICU.

Objective: To assess the impact of introducing a devastating brain injury (DBI) pathway on patient outcome, intensive care unit (ICU) resources, and organ donation practice in the first 3 years of implementation in a regional neurosciences ICU in the South West of England.

Methods: Patients with DBI admitted to our ICU between 2015 and 2018 were identified from our ICU database and their outcomes compared to those of non-DBI patients. Data were also obtained from the national potential donor audit to compare organ donation metrics before and after the introduction of the DBI pathway.

Estimates of the ab initio limit for sulfur-pi interactions: the H2S-benzene dimer.

The interaction between aromatic rings and sulfur atoms in the side chains of amino acids is a factor in the formation and stabilization of alpha-helices in proteins. We studied the H(2)S-benzene dimer as the simplest possible prototype of sulfur-pi interactions. High-quality potential energy curves were obtained using coupled-cluster theory with single, double, and perturbative triple substitutions (CCSD(T)) and a large, augmented quadruple-zeta basis set (aug-cc-pVQZ).