Publications by authors named "Elizabeth D Holland"
Dendritic spines, the mushroom-shaped extensions along dendritic shafts of excitatory neurons, are critical for synaptic function and are one of the first neuronal structures disrupted in neurodevelopmental and neurodegenerative diseases. Microtubule (MT) polymerization into dendritic spines is an activity-dependent process capable of affecting spine shape and function. Studies have shown that MT polymerization into spines occurs specifically in spines undergoing plastic changes.
View Article and Find Full Text PDFDendritic spines, the mushroom-shaped extensions along dendritic shafts of excitatory neurons, are critical for synaptic function and are one of the first neuronal structures disrupted in neurodevelopmental and neurodegenerative diseases. Microtubule (MT) polymerization into dendritic spines is an activity-dependent process capable of affecting spine shape and function. Studies have shown that MT polymerization into spines occurs specifically in spines undergoing plastic changes.
View Article and Find Full Text PDFArticle Synopsis
- Microtubules (MT) are tubular structures made from tubulin that constantly grow and shrink through a process known as dynamic instability, which is influenced by various proteins.
- MTs provide the framework for transporting materials within cells, especially in neurons, which rely on MTs for establishing connections and functioning effectively.
- Recent research highlights the critical role of MT dynamics in synaptic plasticity, suggesting that disruptions in MT stability can significantly affect learning and memory processes.
One overarching goal of gene therapy is the replacement of faulty genes with functional ones. A significant hurdle is presented by the fact that under- or over-expression of a protein may cause disease as readily as coding mutations. There is a clear and present need for pipelines to translate experimentally validated gene therapy strategies to clinical application.
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