Inositol in Disease and Development: Roles of Catabolism via -Inositol Oxygenase in .

Inositol depletion has been associated with diabetes and related complications. Increased inositol catabolism, via -inositol oxygenase (MIOX), has been implicated in decreased renal function. This study demonstrates that the fruit fly catabolizes -inositol via MIOX.

Regulated inositol synthesis is critical for balanced metabolism and development in Drosophila melanogaster.

Myo-inositol is a precursor of the membrane phospholipid, phosphatidylinositol (PI). It is involved in many essential cellular processes including signal transduction, energy metabolism, endoplasmic reticulum stress, and osmoregulation. Inositol is synthesized from glucose-6-phosphate by myo-inositol-3-phosphate synthase (MIPSp).

Disruption of , a Gene Encoding -Inositol Phosphate Synthase, Causes Male Sterility in .

Inositol is a precursor for the phospholipid membrane component phosphatidylinositol (PI), involved in signal transduction pathways, endoplasmic reticulum stress, and osmoregulation. Alterations of inositol metabolism have been implicated in human reproductive issues, the therapeutic effects of drugs used to treat epilepsy and bipolar disorder, spinal cord defects, and diseases including diabetes and Alzheimer's. The sole known inositol synthetic enzyme is -inositol synthase (MIPS), and the homolog in is encoded by the gene.

Expression of 18-wheeler in the follicle cell epithelium affects cell migration and egg morphology in Drosophila.

The Drosophila ovary is a model system for examining the genetic control of epithelial morphogenesis. The somatic follicle cells form a polarized epithelium surrounding the 16-cell germ line cyst. The integrity of this epithelium is essential for the successful completion of oogenesis.