Publications by authors named "Elizabeth D'Antonio"
Safety and immunogenicity of an adjuvanted adhesin vaccine in healthy women with and without histories of recurrent urinary tract infections: results from a first-in-human phase 1 study.
Gary R Eldridge Heidi Hughey Lois Rosenberger Steven M Martin Andrew Marc Shapiro Elizabeth D'Antonio
Hum Vaccin Immunother
May 2021
Article Synopsis
- Antibiotic resistance in gram-negative bacteria is significantly increasing, highlighting the need for new prevention strategies.
- A study developed a vaccine targeting FimH, a protein involved in bacterial adhesion, to prevent recurrent urinary tract infections (UTIs).
- The phase 1 trial involved 67 healthy women and showed that the vaccine was safe, well-tolerated, and induced strong antibody responses, leading to plans for further phase 2 testing.