Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation.

Unlabelled: Blood transcriptional signatures are promising for tuberculosis (TB) diagnosis but have not been evaluated among U.S.

Patients: To be used clinically, transcriptional classifiers need reproducible accuracy in diverse populations that vary in genetic composition, disease spectrum and severity, and comorbidities.