Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells.

The insulinotropic actions of glucagon-like peptide 1 receptor (GLP-1R) in β-cells have made it a useful target to manage type 2 diabetes. Metabolic stress reduces β-cell sensitivity to GLP-1, yet the underlying mechanisms are unknown. We hypothesized that expression is heterogeneous among β-cells and that metabolic stress decreases the number of GLP-1R-positive β-cells.

Shifting perspectives: a confirmatory factor analysis of the working alliance inventory (short form) with high-risk violent offenders.

The Working Alliance Inventory (WAI) is the most widely used measure of the therapeutic alliance. However, previous studies of the factor structure of the WAI have obtained disparate results. This study examined ratings from three rater perspectives (therapists, clients, and observers) in a rehabilitation program for high-risk violent prisoners with high PCL-psychopathy scores.

Do early therapeutic alliance, motivation, and stages of change predict therapy change for high-risk, psychopathic violent prisoners?

Background: Examination of the extent of offenders' engagement in change, and in rehabilitation programmes, is important to understanding success or failure following rehabilitation. In treatment programmes, the alliance between therapist and offender, and the therapy process itself appear central to progress offenders make that may reduce their criminal risk. But research with offenders seldom has measured therapeutic alliance and clinical writing suggests that it is difficult to form an alliance with those not ready to change their behaviour; especially with higher risk and psychopathic offenders.