Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial.

Obstructive sleep apnea (OSA) is associated with increased risk for diabetes, and standard treatment with positive airway pressure (PAP) device shows inconsistent effects on glucose metabolism. Metformin is known to treat and prevent diabetes, but its effects on skeletal muscle mitochondrial function are not completely understood. Here, we evaluate the effects of metformin on glucose metabolism and skeletal muscle mitochondrial function in patients with OSA.

Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice.

Objective: Obesity is a driver of non-alcoholic fatty liver disease (NAFLD), and interventions that decrease body weight, such as bariatric surgery and/or calorie restriction (CR), may serve as effective therapies. This study compared the effects of Roux-en-Y gastric bypass surgery (RYGB) and CR on hepatic function in mice with obesity and NAFLD.

Methods: C57BL/6J mice were fed a high-fat diet to promote obesity.

Bariatric surgery alters mitochondrial function in gut mucosa.

Background: The obesity pandemic has worsened global disease burden, including type 2 diabetes, cardiovascular disease, and cancer. Metabolic/bariatric surgery (MBS) is the most effective and durable obesity treatment, but the mechanisms underlying its long-term weight loss efficacy remain unclear. MBS drives substrate oxidation that has been linked to improvements in metabolic function and improved glycemic control that are potentially mediated by mitochondria-a primary site of energy production.

GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.

Unlabelled: Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act as cellular signals to regulate pancreatic β-cell function. We used electric pulse stimulation (EPS) to induce contraction in C2C12 myotubes and found that treatment of β-cells with EPS-conditioned medium enhanced glucose-stimulated insulin secretion (GSIS).

Exercise in the Prevention and Treatment of Type 2 Diabetes.

Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the predisposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes.

Air Quality Is Predictive of Mistakes in Professional Baseball and American Football.

Air quality is a growing environmental concern that has implications for human physical and mental health. While air pollution has been linked to cognitive disease progression and declines in overall health, the impacts of air quality on athletic performance have not been extensively investigated. Much of the previous research focused on endurance sports indicates that air quality negatively impacts athletic performance; however, the effects of air quality on non-endurance elite team performance remains largely unknown.

Obesity Management in the Primary Prevention of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is the most frequent primary hepatic malignancy and a leading cause of cancer-related death globally. HCC is associated with an indolent clinical presentation, resulting in frequent advanced stage diagnoses where surgical resection or transplant therapies are not an option and medical therapies are largely ineffective at improving survival. As such, there is a critical need to identify and enhance primary prevention strategies to mitigate HCC-related morbidity and mortality.

Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control.

Background: Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle biogenesis and quality control. We have previously identified that a mitochondrial-targeted furazano[3,4-b]pyrazine named BAM15 is orally available and selectively lowers respiratory coupling efficiency and protects against diet-induced obesity in mice.

The Effect of Coach Gender on Competitive Weightlifting Performance for Men and Women Weightlifters.

Gender of coaches relative to their athletes has recently garnered substantial attention in the public, the media, and academia. Relative to sports engulfed in controversy pertaining to men athletes being coached by women, such as professional baseball, basketball, and football, it is more common to see women coach men in competitive weightlifting, though only a small percent of men weightlifters are coached by women. In competitive weightlifting, coaches are responsible for both physically and mentally training athletes, and with the social barriers faced by women in a sport traditionally perceived as masculine, there may be mental training or communication benefits to training with a coach of a certain gender.

Racial Bias in National Football League Officiating.

Racial bias in sport is a prevalent research topic. Much of the previous research regarding bias among referees in sport focused on sports such as baseball, basketball, hockey, and soccer. Professional American football is unique because race is more clearly defined when compared to these other sports.

Determinants of Missed Games Following Concussions in the National Football League.

Concussions in the National Football League (NFL) are a rising topic of concern and debate. With the implementation of new protocols, NFL players are required to be removed from play and must follow specific processes before full return to play after sustaining a concussion. While concussion severity is the primary determinant of time-off, it is possible that other factors associated with player value influence time-off as well.