Publications by authors named "Elizabeth C Feit"
Low dose amphetamine (AMPH) and methylphenidate (MPH, Ritalin(®)) are the most widely prescribed and most effective pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD). Certain low, clinically relevant doses of MPH improve sustained attention and working memory in normal rats, in contrast to higher doses that impair cognitive ability and induce locomotor activity. However, the effects of AMPH of MPH on sustained attention and behavioral inhibition remain poorly characterized.
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- Poor self-control, lack of inhibition, and impulsivity in adolescents lead to increased risky behaviors, which may be linked to ongoing brain development, particularly in areas responsible for decision-making and impulse control.
- The study used adolescent rats to compare their behavior to adult rats in experiments designed to assess learning, behavioral inhibition, and impulsivity without compromising development through excessive food restriction.
- Results showed that adolescent rats responded more impulsively and with less self-control than adults, highlighting the need for valid animal models to further understand the neurobiology behind risk-taking behavior in adolescents.