A preliminary study on a multiresolution-level inverse planning approach for Gamma Knife radiosurgery.

Purpose: With many plan variables to determine, manual forward planning for Gamma Knife (GK) radiosurgery is very challenging. Inverse planning eases GK planning by determining the variables via solving an optimization problem. However, due to the vast search space, most inverse planning algorithms, including the one provided in Leksell GammaPlan (LGP) treatment planning system, have to predetermine the isocenter locations using some geometric methods and then optimize the shot shapes and durations at these preselected isocenters.

Visual acuity, oncologic, and toxicity outcomes with Pd vs. I plaque treatment for choroidal melanoma.

Purpose: To evaluate outcomes of choroidal melanoma patients treated with I or Pd plaque brachytherapy.

Methods And Materials: From 1993 to 2012, our institution treated 160 patients with Pd (56.1%) and 125 patients with I (43.

Factors Influencing Pulmonary Toxicity in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation in the Setting of Total Body Irradiation-Based Myeloablative Conditioning.

Purpose: This study evaluated factors associated with increased risk of pulmonary toxicity (PT) from any cause in pediatric patients after myeloablative conditioning, using total body irradiation (TBI), followed by allogeneic hematopoietic stem cell transplantation (HSCT).

Methods And Materials: The records of 129 consecutive pediatric patients (range: 1-21 years of age) who underwent TBI-based myeloablative conditioning for hematologic malignancies at our institution between January 2003 and May 2014 were reviewed. Although total TBI doses ranged from 10.

Long-term outcomes of IMRT for breast cancer: a single-institution cohort analysis.

Purpose: To evaluate long-term outcomes of adjuvant breast intensity-modulated radiation therapy (IMRT), with a comparison cohort receiving conventional radiation (cRT) during the same period.

Methods And Materials: Retrospective review identified patients with Stages 0-III breast cancer who underwent irradiation after conservative surgery from January 1999 to December 2003. Computed tomography simulation was used to design standard tangential breast fields with enhanced dynamic wedges for cRT and both enhanced dynamic wedges and dynamic multileaf collimators for IMRT.

Quality assurance for computed-tomography simulators and the computed-tomography-simulation process: report of the AAPM Radiation Therapy Committee Task Group No. 66.

This document presents recommendations of the American Association of Physicists in Medicine (AAPM) for quality assurance of computed-tomography- (CT) simulators and CT-simulation process. This report was prepared by Task Group No. 66 of the AAPM Radiation Therapy Committee.

Results of interstitial brachytherapy for malignant brain tumors.

We evaluated the efficacy of brachytherapy in patients with malignant brain tumors and assessed the factors associated with longer disease control after treatment. From June 1989 to October 1995, 73 patients were treated with stereotactic brachytherapy with temporary placement of iodine-125 implants. The median age was 52 (range 9-79).