Publications by authors named "Elizabeth A Shedroff"
Article Synopsis
- Schizophrenia involves significant brain function changes, with insulin signaling pathways, especially AKT, playing a key role in its development.
- This study found increased mRNA levels of AKT1-3 in neurons from schizophrenia patients, while total AKT protein levels remained unchanged or lower, indicating a potential disconnect between gene expression and protein presence.
- The research also revealed sex-specific differences in AKT activity, additional changes in related signaling components, and heightened expression of the glucose metabolism regulator FOXO1, suggesting potential compensatory mechanisms in response to insulin signaling issues.
Schizophrenia is characterized by substantial alterations in brain function, and previous studies suggest insulin signaling pathways, particularly involving AKT, are implicated in the pathophysiology of the disorder. This study demonstrates elevated mRNA expression of AKT1-3 in neurons from schizophrenia subjects, contrary to unchanged or diminished total AKT protein expression reported in previous postmortem studies, suggesting a potential decoupling of transcript and protein levels. Sex-specific differential AKT activity was observed, indicating divergent roles in males and females with schizophrenia.
View Article and Find Full Text PDF