Blood transfusion: friend or foe.

The effectiveness of transfusions is often compromised by adverse reactions. Common transfusion reactions (hemolytic transfusion reactions, transfusion-related acute lung injury, transfusion-associated circulatory overload, transfusion-related immunomodulation) are reviewed, including pathogenesis, clinical and laboratory manifestations, and treatment. In addition, artificial blood substitutes are discussed as a way to mitigate the risk of transfusion-related morbidity and mortality.

Pharmacologic management of the postoperative cardiac surgery patient.

Maintaining adequate cardiac output in postoperative cardiac surgery patients is a complex and challenging feat for health care teams. Alterations in preload, afterload, contractility, heart rate, and rhythm can be devastating to these patients and lead to lethal consequences. An array of pharmacologic therapies is available in the critical care setting to help prevent and treat such complications and ensure satisfactory cardiac performance.