Comparative Safety Profile of the Fixed-Dose Combination Corticosteroid and Long-acting β-Agonist Fluticasone Propionate/Formoterol Fumarate: A 36-Month Longitudinal Cohort Study in UK Primary Care.

Objective: The inhaled corticosteroid/long-acting β-agonist (ICS/LABA) fluticasone propionate/formoterol fumarate (FP/FORM; Flutiform) has been available as fixed-dose combination (FDC) therapy for asthma patients aged ≥ 12 years in the UK since 2012. This post-authorisation safety study examined adverse outcomes and prescribing practices for FP/FORM and other FDC ICS/LABA therapies in a real-life clinical setting over 36 months.

Methods: Historical, longitudinal cohort database study using UK primary care data from the Clinical Practice Research Datalink (CPRD) database, for patients initiated on or switched to an FDC ICS/LABA (ENCePP study number: EUPAS12330).

Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey.

Background: Lower limb mobility disabilities are well understood in older people, but the causes in middle age have attracted little attention.

Objectives: To estimate the prevalence of mobility disabilities among noninstitutionalized adults in England and to compare the disabling symptoms reported by middle-aged and older people.

Design: Cross-sectional data from the 2002 English Longitudinal Study of Ageing (ELSA).

Performance of older adults on tests of cognitive estimation.

This study provides performance data for older adults on two existing tests of cognitive estimation ability (Cognitive Estimation Test [CET] and Temporal Judgement Test [TJT]) and a novel set of estimation questions (n-EQ) that make reference to familiar, everyday objects. It explores the relations between each of the three tests of estimation and verbal intelligence. The sample comprises 101 adults aged 55 years and over.