Occult symptomatic bilateral pure Leydig cell tumors in a postmenopausal woman: a case report.

Background: Pure Leydig cell tumors (LCTs) represent 0.1% of ovarian masses. Postmenopausal patients typically present with virilization.

Racial disparities in molecular subtypes of endometrial cancer.

Objectives: Racial differences in the molecular subtypes of endometrial cancer and associations with progression-free survival (PFS) were evaluated.

Methods: Molecular, clinical and PFS data were acquired from the Cancer Genome Atlas (TCGA) including classification into the integrative, somatic copy number alteration and transcript-based subtypes. The prevalence and prognostic value of the aggressive molecular subtypes (copy number variant [CNV]-high, cluster 4 or mitotic) were evaluated in Black and White patients.

Impact of age at diagnosis on racial disparities in endometrial cancer patients.

Introduction: Although black patients with endometrial cancer (EC) have worse survival compared with white patients, the interaction between age/race has not been examined. The primary objective was to evaluate the impact of age at diagnosis on racial disparities in disease presentation and outcome in EC.

Methods: We evaluated women diagnosed with EC between 1991 and 2010 from the Surveillance, Epidemiology, and End Results.

Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients.

Background: The objective of this study was to identify molecular alterations associated with disease outcomes for white and black patients with endometrioid endometrial cancer (EEC).

Methods: EEC samples from black (n = 17) and white patients (n = 13) were analyzed by proteomics (liquid chromatography-tandem mass spectrometry) and transcriptomics (RNA-seq). Coordinate alterations were validated with RNA-seq data from black (n = 49) and white patients (n = 216).

The use of middle cerebral artery Doppler ultrasonography to guide delivery of a viable pregnancy complicated by metastatic gestational chroriocarinoma.

: Choriocarcinoma is a rare, aggressive subtype of gestational trophoblastic neoplasia. The diagnosis of metastatic choriocarcinoma in the setting of a viable intrauterine pregnancy is exceedingly rare and often associated with feto-maternal hemorrhage. : An otherwise healthy Gravida 1 Para 0 at 34 weeks gestational age presented with metastatic choriocarcinoma and a viable fetus.

Amniotic fluid as a vital sign for fetal wellbeing.

: Amniotic fluid, once thought to merely provide protection and room for necessary movement and growth for the fetus, is now understood to be a highly complex and dynamic system that is studied as a data point to interpret fetal wellbeing. : Assessment of amniotic fluid volume is now routine when performing a sonographic evaluation of fetal status and is an important consideration in the assessment and management of perinatal morbidity and mortality. In this review, we will cover the dynamics that affect amniotic fluid volume, review methods for measurement and quantification of volume, review definitions for normative data as related to neonatal outcomes, and provide evidence based guidance on the workup and management options for oligoydramnios and polyhydramnios in singleton and twin pregnancies.

Borderline or marginal amniotic fluid index and peripartum outcomes: a review of the literature.

The predictive accuracy of a borderline amniotic fluid index (AFI) for an adverse pregnancy outcome is uncertain. Pregnancy outcomes of a borderline versus normal AFI suggest an increased risk of meconium-stained fluid, intrauterine growth restriction, cesarean delivery for a nonreassuring fetal heart rate, low Apgar scores, and neonatal intensive care unit admission with borderline fluid. These results are inconclusive because of study design variations, the absence of receiver-operating characteristic curves, our inability to calculate likelihood ratios, and a lack of randomized trials.

Bilateral sciatic nerve palsy: a new presentation of toilet bowl neuropathy.

Background: Presentations of lower extremity compression palsies are rare and exist only in case reports. The true incidence of emergency department (ED) presentations of bilateral sciatic nerve palsy, "toilet bowl neuropathy," is unknown. The following is a case of a 28-year-old active duty Navy woman who presented to our ED via ambulance with bilateral sciatic nerve palsy from prolonged immobility.