The distribution of mitochondrial activity in relation to optic nerve structure.

Background: The observation of a buildup of mitochondria at the level of the lamina cribrosa in the optic nerve head has traditionally been attributed to axoplasmic stasis. However, this region is also the transition zone for myelination, resulting in differing energy requirements.

Objective: To investigate the relationship between myelination and mitochondrial activity in optic nerve tissue.