Publications by authors named "Elizabete Rocha da Rocha"
Chronic stress and lithium treatments alter hippocampal glutamate uptake and release in the rat and potentiate necrotic cellular death after oxygen and glucose deprivation.
Neurochem Res
May 2011
This study was undertaken to evaluate the effects of chronic variate stress and lithium treatment on glutamatergic activity and neuronal vulnerability of rat hippocampus. Male Wistar rats were simultaneously treated with lithium and submitted to a chronic variate stress protocol during 40 days, and afterwards the hippocampal glutamatergic uptake and release, measured in slices and synaptosomes, were evaluated. We observed an increased synaptosomal [(3)H]glutamate uptake and an increase in [(3)H]glutamate stimulated release in hippocampus of lithium-treated rats.
View Article and Find Full Text PDFChronic lithium treatment has antioxidant properties but does not prevent oxidative damage induced by chronic variate stress.
Neurochem Res
September 2006
This study evaluated the effects of chronic stress and lithium treatments on oxidative stress parameters in hippocampus, hypothalamus, and frontal cortex. Adult male Wistar rats were divided into two groups: control and submitted to chronic variate stress, and subdivided into treated or not with LiCl. After 40 days, rats were killed, and lipoperoxidation, production free radicals, total antioxidant reactivity (TAR) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were evaluated.
View Article and Find Full Text PDFPleasant and unpleasant flavors and odors can modulate pain perception, and the efficacy of sweet flavors in reducing pain seems to be related to its hedonic value. Chronic variate stress paradigm is a model of depression, and is suggested to induce anhedonia. We observed previously that lithium may prevent behavioral and neurochemical alterations induced by chronic stress; so we hypothesized that chronically stressed animals may present different nociceptive response to pleasant and unpleasant tastes that could be prevented by lithium treatment.
View Article and Find Full Text PDFNa+,K(+)-ATPase activity is reduced in hippocampus of rats submitted to an experimental model of depression: effect of chronic lithium treatment and possible involvement in learning deficits.
Neurobiol Learn Mem
September 2005
Article Synopsis
- The study investigated how chronic stress and lithium treatments affect Na+,K(+)-ATPase activity in the hippocampus and spatial memory in rats.
- Two experiments were conducted: the first evaluated Na+,K(+)-ATPase activity after a chronic stress protocol coupled with lithium treatment, while the second assessed spatial memory performance in a Water Maze task during and after stress treatment.
- Results showed that chronic stress impaired both Na+,K(+)-ATPase activity and spatial memory, but these impairments were mitigated by lithium treatment and stress interruption, suggesting lithium's role in treating mood disorders may involve regulating this enzyme activity.