Effects of Chronic Brain Injury on Quality of Life: A Study in Patients With Left- or Right-Sided Lesion.

Objectives: To test the hypothesis that quality of life (QOL) is made up of different components, and each of these has different anatomic and demographic contributors.

Design: Questionnaire-based study.

Setting: Center for Cognitive Neuroscience, University of Pennsylvania.

Impaired Voluntary Control in PTSD: Probing Self-Regulation of the ACC With Real-Time fMRI.

Post-traumatic stress disorder (PTSD) is characterized by deficits in the self-regulation of cognitions and emotions. Neural networks of emotion regulation may exhibit reduced control mediated by the anterior cingulate cortex (ACC), contributing to aberrant limbic responses in PTSD. Real-time fMRI neurofeedback (rt-fMRI NF) assessed self-regulation of the ACC in nine patients with PTSD after single trauma exposure and nine matched healthy controls.