Publications by authors named "Eliza M Ludlam"
Article Synopsis
- The prenylated form of the OAS1 protein effectively inhibits SARS-CoV-2 replication, but this antiviral feature was lost in the horseshoe bat's OAS1 due to the absence of a prenylation signal.
- Researchers recreated the ancestral form of the bat OAS1 protein (RhinoCA OAS1), which retains the ability to block SARS-CoV-2 replication, demonstrating the importance of prenylation for antiviral function.
- The study reveals evolutionary changes in the OAS1 gene in horseshoe bats that likely led to a loss of its protective role against coronaviruses, enhancing our understanding of the virus's relationship with its bat reservoir.
