Publications by authors named "Eliza Dean"
Article Synopsis
- - The study explores the relationship between gut microbiota and heart failure with preserved ejection fraction (HFpEF), highlighting that gut bacteria impacts risk factors like hypertension, obesity, and age, potentially through metabolites like short-chain fatty acids.
- - Researchers analyzed 26 HFpEF patients and 67 controls, utilizing bacterial sequencing to assess gut microbiome diversity, revealing significant differences in both the number and types of microbes present between the two groups.
- - Key findings include a reduction in beneficial gut bacteria related to short-chain fatty acid production in HFpEF patients, who also reported lower fiber intake, suggesting a link between gut health and cardiovascular stability that necessitates further investigation.
Background Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent form of heart failure, representing half of the total burden of heart failure. We hypothesised that modulation of the phosphodiesterase type 3/cyclic AMP using a novel oral formulation of milrinone might exert favorable effects HFpEF via pulmonary and systemic vasodilation and enhancement of ventricular relaxation. We assessed the safety and efficacy of oral milrinone on quality of life and functional outcomes in patients with HFpEF.
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