Publications by authors named "Elismauro Francisco de Mendonca"
Purpose: This study analyzed the immunoexpression of C-X-C chemokine ligand 12 (CXCL12) and C-X-C chemokine receptor 4 (CXCR4) in oral tongue squamous cell carcinoma (OTSCC) of young (≤ 45 years) and older (≥ 60 years) patients and correlated the findings with clinicopathological parameters (sex, tumor size, regional metastasis, clinical stage, and histopathological grade of malignancy).
Methods: Forty OTSCC cases (20 diagnosed in young patients and 20 diagnosed in older patients) were selected. Cytoplasmic (CXCL12 and CXCR4) and nuclear (CXCR4) staining percentages in epithelial and stromal cells were assessed at the invasive tumor front.
Article Synopsis
- Granular Cell Tumor (GCT) is a rare benign oral lesion, often misdiagnosed due to its similarity to other conditions, highlighting the need for more awareness on its prevalence and characteristics.
- A study at six diagnostic centers in Brazil and Argentina analyzed 61 GCT cases, predominantly in females (73.8%), with most tumors on the tongue, presenting as painless nodules or papules in various colors and sizes.
- Histopathological analysis revealed distinctive cell characteristics, with low agreement between clinical and histological diagnoses, but no local recurrences were noted during the follow-up period.
Dermoid cysts (DCs) and epidermoid cysts (ECs) are uncommon developmental cysts affecting the oral cavity. This study aims to evaluate patients with oral DCs and ECs and their demographic and clinicopathologic features. A retrospective descriptive cross-sectional study was performed.
View Article and Find Full Text PDFSociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study.
Clin Oral Investig
November 2023
Article Synopsis
- This multicenter study analyzed 1,341 cases of odontogenic keratocysts from 1,169 patients to explore differences between non-syndromic and syndromic cases, including recurrence rates.
- The study found that non-syndromic cases were more common, with the posterior mandible being the most affected site, and noted that most lesions were unilocular and asymptomatic.
- Conservative treatment was the most frequently used, and recurrences were rare; the study highlighted that clinical features could vary significantly between syndromic and non-syndromic patients.
Article Synopsis
- The study investigated the clinical and pathological characteristics of 19 oral solitary fibrous tumors (SFTs), revealing a predominance in females and an average patient age of 47.3 years.
- Most tumors were found in the buccal mucosa and appeared as asymptomatic nodules; over half exhibited a classic hybrid pattern in their cellular structure.
- All tumors tested positive for specific markers (STAT6 and CD34), and follow-up data indicated no local recurrence in the few patients tracked, underscoring the need for accurate diagnosis by pathologists to avoid misdiagnosis of these rare tumors.
Effects of a mucoadhesive phytomedicine (Curcuma longa L. and Bidens pilosa L.) on radiotherapy-induced oral mucositis and quality of life of patients undergoing head and neck cancer treatment: randomized clinical trial.
Support Care Cancer
August 2023
Article Synopsis
- - This study aimed to evaluate the effectiveness of a herbal medicine (FITOPROT) combined with photobiomodulation (PBM) therapy and a preventive oral care program (POCP) in treating radiotherapy-induced oral mucositis (ROM) and improving quality of life in head and neck cancer patients.
- - A double-blind clinical trial was conducted with two groups: one received PBM and POCP, while the other received these along with FITOPROT mouthwash, with evaluations at various points during treatment.
- - Results showed no significant differences between the groups in terms of ROM severity or quality of life, indicating that the combination treatment did not provide a notable advantage over PBM and POCP alone.
The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information.
View Article and Find Full Text PDFApical periodontitis shows radiographic signs such as widening of the periodontal ligament and periapical radiolucency, which differ in extent depending on the stage of the lesion. However, other lesions can be associated with or coincidental to the apical region, representing developmental lesions and benign or malignant tumours. This article describes three cases of malignant tumours, a central mucoepidermoid carcinoma (CMEC), a chondroblast osteosarcoma and an osteosarcoma of the jaw (OSJ) that presented as periapical lesions.
View Article and Find Full Text PDFThe aim of this study was to investigate the epidemiological and clinical characteristics of chronic inflammatory periapical diseases in different regions of Brazil and to compare with data from the literature. A multicenter study was carried out in four Brazilian referral centers in oral diagnosis. Histopathological records were reviewed, and all cases diagnosed microscopically as periapical granuloma, radicular cyst, and periapical abscess were included.
View Article and Find Full Text PDFWe present the frequency of cases of isolated odontogenic keratocysts submitted to microscopic examination at 10 Brazilian referral centres in Oral and Maxillofacial Pathology. In a retrospective (1953-2017) analysis, data on clinicoradiographic features and treatment of these lesions were collected and analysed descriptively. Among the 258,867 cases retrieved, 2,497 (0.
View Article and Find Full Text PDFThe immunoexpression of p16, p53, and Bax in oral tongue squamous cell carcinoma (OTSCC) in young and elderly patients is assessed based on clinical and morphological parameters. The sample consists of 60 OTSCC cases: 30 in young (age ≤ 45 years) and 30 in elderly (age ≥ 60 years) patients. Clinical (tumor size, regional node metastasis, distant metastasis, and clinical stage) and morphological (histological grade of malignancy) parameters were evaluated.
View Article and Find Full Text PDFRandomized clinical trial of a mucoadhesive formulation containing curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae) extract (FITOPROT) for prevention and treatment of oral mucositis - phase I study.
Chem Biol Interact
August 2018
Preclinical repeated-dose toxicity and efficiency studies developed by our group suggest the potential of FITOPROT in treating mucositis. This serious limiting side effect is observed at a rate of 40-100% in patients under antineoplastic therapy and despite different palliative measures and therapeutic agents have been investigated, still no therapy was completely successful. Therefore, this study aimed to establish the safety and recommended phase II dose of FITOPROT for the prevention and treatment of chemoradiotherapy-induced oral mucositis (OM) in patients with head and neck cancer.
View Article and Find Full Text PDFObjectives: To investigate the frequency of calcifying odontogenic cysts (COCs) that have been submitted for microscopic examination from representative geographic regions of Brazil and to compare it with literature data.
Materials And Methods: A retrospective study was conducted on biopsies obtained from 1953 to 2016 at 10 Brazilian oral and maxillofacial pathology centres. A total of 198,350 biopsy specimens were analysed.
Case Report: The present report describes a case of chondroblastic osteosarcoma in the periapical region of teeth #29, #30, and #31 of an 18-year-old male. Clinical history showed self-reported discomfort in the right posterior gingiva for over a month. Physical examination showed a small expansion and redness of the right mandibular buccal and lingual cortical plates, but no signs of pain or inflammation were observed.
View Article and Find Full Text PDFIntroduction: Several studies towards the development of an effective treatment for intestinal mucositis have been reported, since this condition represents a major problem in clinical oncology practice due to cytotoxic effects of chemotherapy. However standardized protocols and universally accepted treatment options are yet to be established.
Objectives: Given above, this study evaluated the protective effects of a mucoadhesive formulation containing both L.
Objective: To evaluate the detection of mucous retention cyst of maxillary sinus (MRCMS) using panoramic radiography and cone beam computed tomography (CBCT).
Study Design: A digital database with 6,000 panoramic radiographs was reviewed for MRCMS. Suggestive images of MRCMS were detected on 185 radiographs, and patients were located and invited to return for follow-up.
Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important role in tumor-associated immune response. Of these, T regulatory (Treg) cells have also been shown to inhibit anti-tumor response. We aimed to evaluate the expression of T regulatory cell markers (CD4, CD25, CTLA-4 and FoxP3) in samples of oral cavity squamous cell carcinoma (OCSCC) and lip SCC (LSCC) by immunohistochemistry.
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