Publications by authors named "Elisheba Malau"
Article Synopsis
- Typhoid fever, caused by Salmonella enterica serovar Typhi, remains a major health issue in low-income regions, particularly in the Asia-Pacific, and this study analyzes the S. Typhi populations in Papua New Guinea (PNG) over 30 years using whole genome sequencing.
- The research found that PNG's S. Typhi is primarily made up of a single genotype (2.1.7) that originated in Indonesia, showing low evidence of cross-border transmission, and remains largely susceptible to traditional treatment drugs.
- To effectively combat typhoid fever, PNG needs to maintain effective antimicrobial treatments while improving sanitation infrastructure and monitoring for any signs of antimicrobial resistance (AMR) emergence.
Shigella is a common cause of diarrhoea in Papua New Guinea (PNG) and other Oceania countries. However, little is known about the strains causing infection. Archived Shigella isolates (n = 72) were obtained from research laboratories in PNG and reference laboratories in Australia.
View Article and Find Full Text PDFBackground: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of asymptomatic and submicroscopic infections and on transmission potential are yet poorly understood.
Methods: In Papua New Guinea, vector control has been intensified since 2008, and improved diagnosis and treatment was introduced in 2012.
Background: Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level. National malaria programmes require cost-effective and timely ways of characterizing drug-resistance at multiple sites within their countries.
View Article and Find Full Text PDFIntermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and Plasmodium vivax.
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