Publications by authors named "Eliseba Castro"
Int J Mol Sci
January 2024
Article Synopsis
- A recently identified diarylpentanoid shows promise as a growth inhibitor for cancer cells with low toxicity to non-tumor cells, having a GI value of 0.17 to 0.45 µM.
- The compound promotes mitotic arrest by disrupting spindle assembly, resulting in apoptotic cell death.
- A library of analogs was synthesized and tested, revealing four active compounds that caused significant mitotic arrest and enhanced antimitotic effects, with one compound demonstrating the highest efficacy through spindle dynamics interference.
