Cognitive and physiologic correlates of subclinical structural brain disease in elderly healthy control subjects.

Context: Healthy elderly persons commonly show 4 types of change in brain structure-cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities-as forms of subclinical structural brain disease (SSBD).

Objectives: To characterize the volumes of SSBD present with aging and to determine the associations of SSBD, physiology, and cognitive function.

Design: Cross-sectional study.