Biomarkers of kidney function and prediction of death from cardiovascular and other causes in the elderly: A 9-year follow-up study.

Background: Cystatin C is claimed to be superior to creatinine-based estimates of glomerular filtration rate (eGFRcr). The purpose of the study is to analyze whether cystatin C, creatinine, and/or estimated glomerular filtration rates (eGFR) predicted cardiovascular and/or non-cardiovascular deaths among Finnish elderly.

Methods: Hazard ratios (HR) of cystatin C, creatinine and eGFRs for cardiovascular and non-cardiovascular deaths.

Renal impairment associated with diabetes in the elderly.

Objective: To characterize renal impairment associated with diabetes in older adults by serum markers of glomerular filtration rate and microalbuminuria tests.

Research Design And Methods: The study population consisted of 187 diabetic and 1,073 nondiabetic subjects (age range 64-100 years) participating in a cross-sectional, population-based survey in southwestern Finland. Renal function was estimated by serum cystatin C (Cys C), serum creatinine (Cr), and the urinary albumin-to-creatinine ratio, and determinants of elevated levels were assessed by multivariate analysis.

Serum cystatin C in the aged: relationships with health status.

Background: Serum cystatin C (Cys C) is claimed to be superior to serum creatinine (Cr) in estimating glomerular filtration rate, but its utility in assessing renal function in the polymorbid elderly needs to be evaluated.

Methods: In a cross-sectional, community-based survey performed in Lieto in southwestern Finland, Cys C, Cr, and urinary albumin-creatinine ratio (ACR) were measured in 1,260 subjects aged 64 to 100 years. Associations of demographic characteristics and health status factors with levels of Cys C, Cr, and ACR were assessed by means of linear models.