Publications by authors named "Elise S Andersen"
Adipose tissue takes up glucose and releases lactate, thereby contributing significantly to systemic glucose and lactate homeostasis. This implies the necessity of upregulation of net acid and lactate flux capacity during adipocyte differentiation and function. However, the regulation of lactate- and acid/base transporters in adipocytes is poorly understood.
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- The study developed stable human brown and white pre-adipocyte cell models by integrating the human telomerase reverse transcriptase (TERT), allowing for extensive testing of their characteristics and functions.
- Results showed that brown adipocytes (TERT-hBA) had higher levels of thermogenic activity and were more responsive to stimulation compared to white adipocytes (TERT-hWA), which can still undergo 'browning' to gain some brown fat characteristics.
Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold-exposed mice. Accordingly, these genes were also induced after β-adrenergic activation of cultured brown adipocytes, concomitant with accumulation of hypoxia inducible factor-1α (HIF-1α) protein levels.
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