The Paralogous Genes and , Encoding Multidrug Resistance ABC Transporters, Derive From a Recent Duplication Event, Being Specific to the Genus.

Pleiotropic drug resistance (PDR) family of ATP-binding cassette (ABC) transporters play a key role in the simultaneous acquisition of resistance to a wide range of structurally and functionally unrelated cytotoxic compounds in yeasts. Pdr18 was proposed to transport ergosterol at the plasma membrane, contributing to the maintenance of adequate ergosterol content and decreased levels of stress-induced membrane disorganization and permeabilization under multistress challenge leading to resistance to ethanol, acetic acid and the herbicide 2,4-D, among other compounds. is a paralog of , first described as a determinant of resistance to the chemical mutagen 4-NQO.