Cellular Activity of Typhimurium ArtAB Toxin and Its Receptor-Binding Subunit.

Salmonellosis is among the most reported foodborne illnesses in the United States. The Typhimurium DT104 phage type, which is associated with multidrug-resistant disease in humans and animals, possesses an ADP-ribosylating toxin called ArtAB. Full-length AB has been found on a number of broad-host-range non-typhoidal species and serovars.

Evaluation of the Efficacy of a Cholera-Toxin-Based Vaccine against Bovine Intramammary Challenge.

() is a primary agent of bovine mastitis and a source of significant economic loss for the dairy industry. We previously reported antigen-specific immune induction in the milk and serum of dairy cows following vaccination with a cholera toxin A and B subunit (CTA/B) based vaccine containing the iron-regulated surface determinant A (IsdA) and clumping factor A (ClfA) antigens of (IsdA + ClfA-CTA/B). The goal of the current study was to assess the efficacy of this vaccine to protect against infection after intramammary challenge.