Publications by authors named "Elise Mank"

Importance: Feeding intolerance is a common condition among preterm infants owing to immaturity of the gastrointestinal tract. Enteral insulin appears to promote intestinal maturation. The insulin concentration in human milk declines rapidly post partum and insulin is absent in formula; therefore, recombinant human (rh) insulin for enteral administration as a supplement to human milk and formula may reduce feeding intolerance in preterm infants.

View Article and Find Full Text PDF

Background & Aims: Donor human milk (DHM) is recommended as the first alternative for preterm infants if their mother's own milk is not available or if the quantity is not sufficient. The most commonly used technique to eliminate microbial contaminants in DHM is holder pasteurization (HoP). However, the heating process during HoP partially destroys milk bioactive factors such as insulin.

View Article and Find Full Text PDF
Article Synopsis
  • - The study examines how insulin levels in human milk (HM) change in the first ten days after birth, particularly focusing on preterm infants who may benefit from these levels for better digestive health.
  • - Results show that HM insulin concentration decreases quickly in the first three days, stabilizing afterward, is higher in milk from obese mothers, and follows a daily pattern of varying levels.
  • - The research indicates that preterm delivery does not significantly impact HM insulin levels when considering the mother's pre-pregnancy weight, suggesting that maternal factors, like obesity, play a more crucial role.
View Article and Find Full Text PDF

Human milk (HM) contains numerous non-nutritive bioactive factors, amongst which the peptide hormone insulin. HM insulin has been suggested to accelerate intestinal maturation, thereby promoting feeding tolerance. Therefore, recombinant human insulin for enteral administration has been developed which might serve as supplement to HM or formula for preterm infants.

View Article and Find Full Text PDF
Article Synopsis
  • Feeding preterm infants with their mother's milk can lead to fewer health issues and better brain development, prompting research into the beneficial components of human milk for developing nutritional supplements.
  • This systematic review aimed to summarize the bioactive factors studied in randomized controlled trials for preterm infant nutrition and to highlight ongoing clinical trials.
  • A total of 17 bioactive factors were examined in 26 studies, but further high-quality research is needed to confirm their effectiveness before they can be widely used in medical practice, with three large trials currently underway on enteral insulin and vitamin A.
View Article and Find Full Text PDF

Background & Aims: Experimental (nutritional) interventions in preterm infants frequently focus on intestinal maturation, as improving tolerance to enteral nutrition is a major goal. Intestinal permeability and lactase activity serve as markers for intestinal maturation. We aimed to develop a protocol for the simultaneous assessment of both markers in human-milk-fed preterm infants by a sugar absorption test.

View Article and Find Full Text PDF

Objective: When own mother's milk falls short, pasteurized human donor milk is recommended as alternative feeding for preterm infants. Donor milk has to meet the highest safety standards, but its processing and storage is expensive. The recommended storage time of pasteurized donor milk is 3 months.

View Article and Find Full Text PDF

Importance: Infections and necrotizing enterocolitis, major causes of mortality and morbidity in preterm infants, are reduced in infants fed their own mother's milk when compared with formula. When own mother's milk is not available, human donor milk is considered a good alternative, albeit an expensive one. However, most infants at modern neonatal intensive care units are predominantly fed with own mother's milk.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionepbi9jl4gne2ntcvc5tca7iepgf7i42t): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once