Publications by authors named "Elise Leclercq"
Article Synopsis
- A new method for efficiently opening imidazoheterocycles through direct C-H azidation has been developed, leading to the formation of N-heterocyclic amides.
- This process uses convergent paired electrolysis, allowing for the creation of a variety of pyridylbenzamides with yields ranging from moderate to excellent, all without the need for external oxidants, electrolytes, or metals.
- The methodology has been adapted to continuous flow conditions, resulting in significant cost savings compared to traditional batch processing methods.
An efficient and versatile protocol for the C-H sulfonylation of imidazoheterocycles electrochemical activation was established under batch and flow conditions. The selective C-H bond functionalization proceeded under catalyst- and oxidant-free conditions and tolerated a wide range of functional groups. Various sodium sulfinates as well as imidazo[1,2-]-pyridines, -pyrimidine, -quinolines, and -isoquinolines, imidazo[1,2-]pyridazine, imidazo[2,1-]thiazoles and benzo[]imidazo[1,2-]thiazoles reacted successfully.
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