Publications by Elise C O'Donnell

Publications by authors named "Elise C O'Donnell"

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The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists.

Mark Reid Ian Carlyle Wilson L Caulfield Tom R Clarkson Fiona Cusick Elise C O'Donnell

Bioorg Med Chem Lett

June 2010

Antagonists of the 5-HT(6) receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer's disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides-a novel chemotype of 5-HT(6) antagonists.

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