Random Forest Model Predictions Afford Dual-Stage Antimalarial Agents.

The need for novel antimalarials is apparent given the continuing disease burden worldwide, despite significant drug discovery advances from the bench to the bedside. In particular, small-molecule agents with potent efficacy against both the liver and blood stages of parasite infection are critical for clinical settings as they would simultaneously prevent and treat malaria with a reduced selection pressure for resistance. While experimental screens for such dual-stage inhibitors have been conducted, the time and cost of these efforts limit their scope.

Biomimetic strategies to produce catalytically reactive CuS nanodisks.

Copper sulfide materials have diverse applications from cancer therapy to environmental remediation due to their narrow bandgap and easily tuned plasmon. The synthesis of these materials often involves toxic reagents and harsh conditions where biomimetic methods may provide opportunities to produce these structures under sustainable conditions. To explore this capability, simple amino acids were exploited as biological ligands for the ambient synthesis of CuS materials.