Publications by authors named "Elise Bonnet"
Article Synopsis
- The study focused on individualized dosing of niraparib for patients with platinum-sensitive recurrent ovarian cancer (PSROC), revealing that most patients required treatment modifications due to adverse events (AEs) during the first three months.
- A significant proportion of patients (62%) experienced AEs, with common issues including fatigue, insomnia, and thrombocytopenia, highlighting the physical and emotional burden of the therapy.
- The findings indicated that physicians often underestimated these symptoms, emphasizing the importance of patient self-reporting for a comprehensive understanding of treatment-related challenges.
A thermal sensor was used to better understand parameters which influenced the interaction between a laser beam and a 0.5% Mn-doped ZnAlO material, especially the laser defocusing parameter. The optical properties of the material depend on whether the Mn ions occupy octahedral and/or tetrahedral sites depending on thermal history.
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- A specific type of metastatic triple-negative breast cancer (mTNBC) shows increased sensitivity to platinum-based chemotherapy due to homologous recombination deficiency (HRD), prompting a study to explore genetic alterations and their impact on treatment response.
- In a study involving mTNBC patients, tumors were analyzed for mutations in 19 HRR genes, and patients were grouped based on their molecular status to evaluate responses to platinum therapy.
- Results indicated that mutations in specific HRR genes and promoter methylation were linked to better disease control, suggesting that broader genetic evaluations could help identify more patients who might benefit from platinum treatment.
West Nile virus (WNV) and Wesselsbron virus (WSLV) are mosquito-borne viruses belonging to the Flavivirus genus, family Flaviviridae and cause outbreaks in southern Africa after heavy rain. Isothermal assays have been proposed for application in field situations as well as low resource settings and hence we developed a reverse-transcriptase recombinase polymerase amplification (RT-RPA) to detect WNV and WSLV known to occur in South Africa, causing sporadic outbreaks usually associated with good rainfall favouring mosquito breeding. Infectious virus can only be handled within a biosafety level (BSL) 3 facility, hence we opted to validate the assay with transcribed RNA.
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