Publications by authors named "Elisangela M Lima"
Article Synopsis
- A recent outbreak of polymyxin-carbapenem-resistant Klebsiella pneumoniae (PCR-Kp) in Rio de Janeiro highlighted the emergence of untreatable infections, necessitating hospital-wide surveillance since December 2014.
- Whole-genome sequencing revealed similarities and differences in genetic traits linked to resistance and virulence among the bacteria, with 10% of tested cases showing a concerning drug-resistant profile.
- The study emphasizes the need for further research to understand the connection between bacterial genetics and clinical outcomes, particularly in patients with existing health issues and limited treatment options.
Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study.
Antibiotics (Basel)
December 2022
A clinical-epidemiological score to predict CR-GNB sepsis to guide empirical antimicrobial therapy (EAT), using local data, persists as an unmet need. On the basis of a case-case-control design in a prospective cohort study, the predictive factors for CR-GNB sepsis were previously determined as prior infection, use of mechanical ventilation and carbapenem, and length of hospital stay. In this study, each factor was scored according to the logistic regression coefficients, and the ROC curve analysis determined its accuracy in predicting CR-GNB sepsis in the entire cohort.
View Article and Find Full Text PDFGeographical information system and spatial-temporal statistics for monitoring infectious agents in hospital: a model using Klebsiella pneumoniae complex.
Antimicrob Resist Infect Control
June 2021
Background: The emergence and spread of antimicrobial resistance and infectious agents have challenged hospitals in recent decades. Our aim was to investigate the circulation of target infectious agents using Geographic Information System (GIS) and spatial-temporal statistics to improve surveillance and control of healthcare-associated infection and of antimicrobial resistance (AMR), using Klebsiella pneumoniae complex as a model.
Methods: A retrospective study carried out in a 450-bed federal, tertiary hospital, located in Rio de Janeiro.
Predictive factors for sepsis by carbapenem resistant Gram-negative bacilli in adult critical patients in Rio de Janeiro: a case-case-control design in a prospective cohort study.
Antimicrob Resist Infect Control
August 2020
Background: Studies have investigated risk factors for infections by specific species of carbapenem-resistant Gram-negative bacilli (CR-GNB), but few considered the group of GNB species and most of them were performed in the setting of bacteremia or hospital infection. This study was implemented to identify risk factors for sepsis by CR- and carbapenem-susceptible (CS) GNB in intensive care unit (ICU) patients to improve management strategies for CR-GNB sepsis.
Methods: We developed a case-case-control study from a prospective cohort of patients with systemic inflammatory response syndrome (SIRS), sepsis-2 or sepsis-3 criteria in which blood and other sample cultures were collected and antimicrobial therapy was instituted, in an adult clinical-surgical ICU, at tertiary public hospital in Rio de Janeiro, from August 2015 through March 2017.