Publications by authors named "Elisabetta Grazia Tomarchio"
Article Synopsis
- Positron Emission Tomography (PET) is a key imaging method in molecular medicine, enabling non-invasive visualization of biological processes at the molecular level.
- Antibody-based PET imaging is becoming increasingly important for targeted disease detection and treatment.
- The article discusses various antibody conjugation techniques, bioconjugation reactions, and new advancements in radiolabeling, aiming to enhance PET imaging for personalized medicine.
Bioorthogonal reactions have revolutionized chemical biology by enabling selective chemical transformations within living organisms and cells. This review comprehensively explores bioorthogonal chemistry, emphasizing inverse-electron-demand Diels-Alder (IEDDA) reactions between tetrazines and strained dienophiles and their crucial role in chemical biology and various applications within the human body. This highly reactive and selective reaction finds diverse applications, including cleaving antibody-drug conjugates, prodrugs, proteins, peptide antigens, and enzyme substrates.
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