Publications by authors named "Elisabetta Daleffe"

Article Synopsis
  • The study investigates the effectiveness and tolerability of oral procainamide versus mexiletine for treating recurrent ventricular arrhythmias in patients who didn't respond to standard therapies like amiodarone and beta-blockers.
  • Out of 68 patients treated, approximately 56% experienced a significant reduction in arrhythmia burden, with procainamide showing nearly three times higher efficacy compared to mexiletine.
  • Side effects were noted in both treatments, but procainamide had a lower discontinuation rate due to severe side effects, suggesting it may be a preferable option for this patient group.
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Background: The ablation of arrhythmias arising near the His-bundle region in the non-coronary aortic cusp (NCAC) is challenging. Among the aortic sinuses of Valsalva, the NCAC is located between the right atrium and the left atrium. For this reason, pacing from the NCAC should result in atrial capture while pacing from the right and left coronary cusps (LCC) may result in ventricular capture.

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Article Synopsis
  • The study examines the effectiveness and safety of oral procainamide for treating recurrent ventricular arrhythmias in patients who did not respond to standard therapies like amiodarone or beta-blockers.! -
  • A total of 34 patients participated, with results showing that procainamide significantly reduced both the number of implantable cardioverter-defibrillator (ICD) interventions and the frequency of ventricular tachycardia/ventricular fibrillation episodes over a treatment period of around 13 months.! -
  • Despite some patients experiencing severe side effects that required therapy discontinuation, the overall tolerability of procainamide was deemed acceptable, indicating it as a viable option for these patients.
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Introduction: The recently developed second-generation subcutaneous implantable cardioverter defibrillator (S-ICD) and the intermuscular two-incision implantation technique demonstrate potential favorable features that reduce inappropriate shocks and complications. However, data concerning large patient populations are lacking. The aim of this multicentre prospective study was to evaluate the safety and outcome of second-generation S-ICD using the intermuscular two-incision technique in a large population study.

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Background: Non-sustained ventricular tachycardia (NSVT) can occur asymptomatically and can be incidentally detected in the internal records of pacemakers (PM). The clinical value of NSVT in the population of PM patients is still uncertain.Our aim was to assess the prevalence of NSVT detected by remote PM control, to describe the clinical and demographic characteristics of patients with NSVT, and to assess the prognostic significance of NSVT in terms of both overall and cardiovascular mortality.

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Background: Our aim was to evaluate the clinical outcome of paroxysmal atrial fibrillation (AF) ablation with contact force technology, using an automated lesion tagging system (VISITAG module) with strict criteria of catheter stability.

Methods and results: We enrolled 200 consecutive patients who underwent pulmonary vein isolation (PVI) in 11 centers and were followed up for 12 months. The stability setting was within 3 mm for ≥10 s and for ≥15 s in 47% and 53% of patients, respectively.

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Aims: The aim of this prospective multicentre study is to evaluate safety and efficacy of the new bidirectional rotational mechanical lead extraction (LE) sheath (Evolution RL, Cook Medical, USA) in chronically implanted leads (>1-year-old leads).

Methods And Results: Between September 2013 and June 2016, a total of 238 leads in 124 consecutive patients were removed by using the new Evolution RL rotational mechanical sheath. Indications for LE were cardiac device infection in 63 (50.

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Background: The traditional technique for subcutaneous implantable cardioverter defibrillator (S-ICD) implantation, which involves three incisions and a subcutaneous pocket, is associated with possible complications, including inappropriate interventions. The aim of this prospective multicenter study was to evaluate the efficacy and safety of an alternative intermuscular two-incision technique for S-ICD implantation.

Methods: The study population included 36 consecutive patients (75% male, mean age 44 ± 12 years [range 20-69]) who underwent S-ICD implantation using the intermuscular two-incision technique.

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Article Synopsis
  • Noncoronary aortic cusp (NCAC) is a complex area for treating focal atrial tachycardias (ATs), especially near the His-bundle, and this study updates findings on catheter ablation techniques for these cases.
  • The study involved 23 patients (predominantly women, average age of 65) with severe symptoms, where mapping guided the ablation directly from NCAC, utilizing a specific catheter for the procedure.
  • Results showed a 95% success rate in eliminating arrhythmias without complications over an average follow-up period of about 41 months, confirming the procedure's safety and effectiveness.
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Aims: Implantable cardioverter defibrillators improve survival of patients at risk for ventricular arrhythmias, but inappropriate shocks occur in up to 30% of patients and have been associated with worse quality of life and prognosis. In heart failure patients with cardiac resynchronization therapy defibrillators (CRT-Ds), we evaluated whether a new generation of detection and discrimination algorithms reduces inappropriate shocks.

Methods And Results: We analysed 1983 Medtronic CRT-D patients (80% male, 67 ± 10 years), 1368 with standard devices (Control CRT-D) and 615 with new generation devices (New CRT-D).

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Background: Routine diagnostic work-up occasionally does not identify any abnormality among patients with monomorphic ventricular arrhythmias (VAs) of left ventricular (LV) origin. Aim of this study was to investigate the value of cardiac MRI (cMRI) for the diagnostic work-up and prognostication of these patients.

Methods And Results: Forty-six consecutive patients (65% males; mean age, 44±15 years) with monomorphic VAs of LV origin and negative routine diagnostic work-up were included.

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We report a case of a false asystole detected by an implantable loop recorder a few days after its implantation. In the discussion section we try to give some hints to help cardiac electrophysiologists in distinguish true from false asystoles, in order to avoid unuseful and potentially dangerous implantations of pacemakers.

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There are no parameters predicting the individual probability of "full response" to cardiac resynchronization therapy (CRT). The aim of this work was to find prognostic factors of full clinical and echocardiographic responses (i.e.

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