Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract.

Phenolic constituents of (Salicaceae) and antiproliferative activity of an extract and individual compounds were investigated in immortalized human non-tumorigenic keratinocytes (HaCaT). A MeOH extract from aerial parts afforded several flavonoids, including luteolin and apigenin glycosides (- and ) and catechin (), two procyanidin fractions, and the phenolic glucosides picein (), triandrin (), and salicortin (). In an adenosine triphosphate assay, the MeOH extract reduced cell viability by approximately 60 % at a concentration of 100 µg/mL.

New Secoiridoid Glucoside, and a Metabolite Profile of Scabiosa lucida.

ourteen secondary metabolites, including a new secoiridoid glucoside (1), were isolated from the aerial parts of Scabiosa licida by a combination of column hromatography, preparative and semi-preparative HPLC. They were identified by extensive NMR, and ESI-MS experiments, and by comparison with iterature data.

New Acylated Flavonol Glycosides and a Phenolic Profile of Pritzelago alpina, a Forgotten Edible Alpine Plant.

Thirteen acylated flavonoid glycosides, 1-13, including eleven new congeners, 3-13, were isolated from the aerial parts of Pritzelago alpina (Brassicaceae) by a combination of column chromatography on Sephadex LH-20, and preparative and semi-preparative HPLC. The structures were established by extensive NMR and MS experiments in combination with acid hydrolysis and sugar analysis by GC/MS. The new compounds were shown to be kaempferol and quercetin glycosides acylated for most of them by a branched short chain fatty acid or a hydroxycinnamic acid residue on the sugar portion.

Differences in indoor versus outdoor concentrations of ultrafine particles, PM2.5, PMabsorbance and NO2 in Swiss homes.

Indoor air quality is a growing concern as we spend the majority of time indoors and as new buildings are increasingly airtight for energy saving purposes. For a better understanding of residential indoor air pollution in Switzerland we conducted repeated 1-2-week-long indoor and outdoor measurements of particle number concentrations (PNC), particulate matter (PM), light absorbance of PM2.5 (PMabsorbance) and nitrogen dioxide (NO2).

Application of land use regression modelling to assess the spatial distribution of road traffic noise in three European cities.

Noise prediction models and noise maps are used to estimate the exposure to road traffic noise, but their availability and the quality of the noise estimates is sometimes limited. This paper explores the application of land use regression (LUR) modelling to assess the long-term intraurban spatial variability of road traffic noise in three European cities. Short-term measurements of road traffic noise taken in Basel, Switzerland (n=60), Girona, Spain (n=40), and Grenoble, France (n=41), were used to develop two LUR models: (a) a "GIS-only" model, which considered only predictor variables derived with Geographic Information Systems; and (b) a "Best" model, which in addition considered the variables collected while visiting the measurement sites.

Comprehensive analysis of Cirsium spinosissimum Scop., a wild alpine food plant.

Plants which have been traditionally eaten by alpine populations may provide new opportunities of agricultural development for mountain regions. In this context we investigated the chemical composition of Cirsium spinosissimum (Asteraceae), a perennial thistle. Its receptacles were eaten by shepherds in Valais (Switzerland).