Publications by authors named "Elisabeth Wilde"
Article Synopsis
- A study found that changes in the brain entorhinal cortex (EC) and specific blood lipids are linked to Alzheimer's disease (AD) in individuals with the apolipoprotein E ε4 genetic variant.
- Analysis of brain imaging and lipid profiles revealed that ε4 carriers with mild traumatic brain injury (mTBI) had thicker left ECs, but repeated mTBIs reduced right EC thickness.
- The research highlights the need for further investigation into the relationship between ε4, mTBI, and specific blood lipid ratios as potential biomarkers for early detection of AD in affected individuals.
Importance: Blast-related mild traumatic brain injuries (TBIs), the "signature injury" of post-9/11 conflicts, are associated with clinically relevant, long-term cognitive, psychological, and behavioral dysfunction and disability; however, the underlying neural mechanisms remain unclear.
Objective: To investigate associations between a history of remote blast-related mild TBI and regional brain volume in a sample of US veterans and active duty service members.
Design, Setting, And Participants: Prospective cohort study of US veterans and active duty service members from the Long-Term Impact of Military-Relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC), which enrolled more than 1500 participants at 5 sites used in this analysis between 2014 and 2023.
Article Synopsis
- Neuroscience researchers are leveraging Big Data to improve the reliability of findings by increasing sample sizes and addressing replication issues.
- A study analyzed data from 53 studies with over 10,500 participants to connect scores from various auditory verbal learning tasks (AVLTs) while controlling for site-related effects.
- The research successfully reduced score variance by 37% and developed an online tool to help researchers and clinicians convert memory scores across different tests, highlighting the benefit of global data harmonization in behavioral sciences.
The past decade has seen impressive advances in neuroimaging, moving from qualitative to quantitative outputs. Available techniques now allow for the inference of microscopic changes occurring in white and gray matter, along with alterations in physiology and function. These existing and emerging techniques hold the potential of providing unprecedented capabilities in achieving a diagnosis and predicting outcomes for traumatic brain injury (TBI) and a variety of other neurological diseases.
View Article and Find Full Text PDFAim: We examined associations among injury severity, white matter structural connectivity within functionally defined brain networks and psychosocial/adaptive outcomes in children with traumatic brain injury (TBI).
Method: Participants included 58 youths (39 male) with complicated-mild TBI (cmTBI; = 12, age = 12.6 ± 2.
Article Synopsis
- - The study examined how concussions affect individuals' ability to perform dual-tasks—specifically, walking while talking—compared to completing single tasks like walking or speaking alone.
- - Participants with concussions showed slower walking speeds and longer speech pauses during dual-tasking, but there were no major differences in speech pauses between concussion and control groups.
- - Strong links were found between dual-task performance and vestibular symptoms, indicating that post-concussion symptoms can significantly impact daily activities like walking and talking simultaneously.
Purpose: To compare the performance of multi-echo (ME) and time-division multiplexing (TDM) sequences for accelerated relaxation-diffusion MRI (rdMRI) acquisition and to examine their reliability in estimating accurate rdMRI microstructure measures.
Method: The ME, TDM, and the reference single-echo (SE) sequences with six TEs were implemented using Pulseq with single-band (SB) and multi-band 2 (MB2) acceleration factors. On a diffusion phantom, the image intensities of the three sequences were compared, and the differences were quantified using the normalized RMS error (NRMSE).
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to understand lifetime exposure to mild traumatic brain injuries (TBIs) among U.S. military service members and Veterans, focusing on differences between male and female participants.
- It involved analyzing data from a large longitudinal study, measuring various characteristics of mild TBIs through structured interviews.
- Results indicated that female service members reported fewer TBIs overall and during deployment compared to males, highlighting significant sex-related differences in injury patterns prior to and during military service.
Article Synopsis
- This study explores the connection between white matter hyperintensities (WMHs), mild traumatic brain injury (mTBI), age, and cognitive performance in a group of combat-exposed Veterans and Service Members.
- The research involved 1,011 participants, revealing that both groups had similar rates of WMHs; however, older individuals with mTBI showed a higher count of WMHs compared to those without.
- Significant relationships were found linking increased WMHs with cognitive impairments in memory and processing speed, suggesting the need for further investigation on the long-term effects of WMHs in mTBI cases.
Purpose: To compare the performance of multi-echo (ME) and time-division multiplexing (TDM) sequences for accelerated relaxation-diffusion MRI (rdMRI) acquisition and to examine their reliability in estimating accurate rdMRI microstructure measures.
Method: The ME, TDM, and the reference single-echo (SE) sequences with six echo times (TE) were implemented using Pulseq with single-band (SB-) and multi-band 2 (MB2-) acceleration factors. On a diffusion phantom, the image intensities of the three sequences were compared, and the differences were quantified using the normalized root mean squared error (NRMSE).
This proof-of-concept study was to investigate the relationship between photobiomodulation (PBM) and neuromuscular control. The effects of concussion and repetitive head acceleration events (RHAEs) are associated with decreased motor control and balance. Simultaneous intranasal and transcranial PBM (itPBM) is emerging as a possible treatment for cognitive and psychological sequelae of brain injury with evidence of remote effects on other body systems.
View Article and Find Full Text PDFObjective: The long-term consequences of traumatic brain injury (TBI) on brain structure remain uncertain. Given evidence that a single significant brain injury event increases the risk of dementia, brain-age estimation could provide a novel and efficient indexing of the long-term consequences of TBI. Brain-age procedures use predictive modeling to calculate brain-age scores for an individual using structural magnetic resonance imaging (MRI) data.
View Article and Find Full Text PDFBackground And Objectives: Traumatic brain injury (TBI) is a concern for US service members and veterans (SMV), leading to heterogeneous psychological and cognitive outcomes. We sought to identify neuropsychological profiles of mild TBI (mTBI) and posttraumatic stress disorder (PTSD) among the largest SMV sample to date.
Methods: We analyzed cross-sectional baseline data from SMV with prior combat deployments enrolled in the ongoing Long-term Impact of Military-relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium prospective longitudinal study.
To determine whether early structural brain trajectories predict early childhood neurodevelopmental deficits in complex CHD patients and to assess relative cumulative risk profiles of clinical, genetic, and demographic risk factors across early development. : Term neonates with complex CHDs were recruited at Texas Children's Hospital from 2005-2011. Ninety-five participants underwent three structural MRI scans and three neurodevelopmental assessments.
View Article and Find Full Text PDFBackground And Purpose: Sport-specific training may improve postural control, while repetitive head acceleration events (RHAEs) may compromise it. Understanding the neural mechanisms underlying postural control may contextualize changes due to training and RHAE. The goal of this study was to determine whether postural sway during the Balance Error Scoring System (BESS) is related to white matter organization (WMO) in collegiate athletes.
View Article and Find Full Text PDFArticle Synopsis
- Resting state functional magnetic resonance imaging (rsfMRI) is a valuable tool for studying brain connectivity, particularly in relation to neurological disorders like traumatic brain injury (TBI), but there is a lack of standardization in how it is used across different research groups.
- This narrative review aims to tackle key methodological challenges in rsfMRI research for TBI by providing recommendations for data acquisition, processing, and analysis to enhance the reliability and comparability of study results.
- The review consists of a literature search on current rsfMRI studies, a set of seven recommendations for improving research practices, and a discussion of future research directions to promote rigorous methods and transparency in the TBI research community.
Article Synopsis
- MRI is a key tool in researching diagnostic and prognostic markers after traumatic brain injury (TBI), particularly to understand mild TBI (mTBI), but findings are often inconsistent, highlighting the need for further study.
- The study analyzed MRI data from 976 military veterans and service members to explore the links between imaging outcomes and clinical features of mTBI, using regression models to account for factors like age and sex.
- Results indicated that while no major differences were found between those with and without mTBI history, blast-related mTBI showed significant brain volume reductions in certain areas, and multiple mTBIs correlated with specific MRI findings.
Intimate partner violence (IPV) is a significant, global public health concern. Women, individuals with historically underrepresented identities, and disabilities are at high risk for IPV and tend to experience severe injuries. There has been growing concern about the risk of exposure to IPV-related head trauma, resulting in IPV-related brain injury (IPV-BI), and its health consequences.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between traumatic brain injury (TBI) and changes in brain connectivity, particularly in military personnel with different histories of TBI during combat versus non-combat situations.
- It focuses on how functional connectivity (FC) in brain regions related to movement, like the basal ganglia, varies depending on the context of the injuries.
- The results reveal that those with deployment-related mild TBI have increased connectivity in certain brain areas, while non-deployment mild TBI was linked to significant correlations with walking performance, suggesting different behavioral outcomes based on the circumstances of the injury.*
Article Synopsis
- * Analyzing data from 1456 service members, the research finds that those with one or more mild TBIs have significantly higher odds of experiencing moderate to severe depression compared to individuals without such injuries.
- * The findings indicate that multiple TBIs and injuries sustained in combat-related contexts are linked to greater depressive symptoms, regardless of the presence of post-traumatic stress disorder (PTSD).
Article Synopsis
- Pediatric brain tumor survivors (PBTS) face neurocognitive challenges, particularly in working memory and processing speed, which may be related to white matter (WM) pathways in the brain.
- The study involved 13 PBTS and 10 healthy controls (HC), examining their cognitive performance and using MRI to analyze WM microstructure.
- Results indicated that PBTS had significantly lower neurocognitive performance and exhibited higher mean diffusivity in key WM areas, suggesting that these microstructure alterations are linked to their cognitive difficulties.
Importance: Traumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive functioning.
Objective: To investigate alterations in subregional cerebellum volume and cerebral white matter microstructure after pediatric TBI and examine subsequent changes in executive function.
Exposure to blast overpressure has been a pervasive feature of combat-related injuries. Studies exploring the neurological correlates of repeated low-level blast exposure in career "breachers" demonstrated higher levels of tumor necrosis factor alpha (TNFα) and interleukin (IL)-6 and decreases in IL-10 within brain-derived extracellular vesicles (BDEVs). The current pilot study was initiated in partnership with the U.
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